A case of verruciform xanthoma and its DNA histogram of nuclei

Abstract

Verruciform xanthoma is a painless verrucous and parakeratinized lesion that appears in the oral cavity. The lesion of our case was located in the lower gingiva of a 55-year-old man.Clinically, the lesion may be confused with papilloma, leukoplakia and verrucous carcinoma. Although we suspected leukoplakia, a malignant disease could not been excluded. Therefore, we measured DNA content of this lesion using flow cytometry. DNA histogram showed a ploidy pattern suggesting nonmalignant lesion. We present a case of verruciform xanthoma with a review of literature, and a clinical use of flow cytometry as a rapid diagnosis in this paper.