Abstract
A case of radiation-induced osteosarcoma is reported. A 43-year-old woman developed mandibular osteosarcoma 28 years after receiving radiotherapy with 60Co (dose unknown) for hemangioma in the oral and neck region.
Hemangioma remained in a wide area surrounding the malignant tumor, making it inoperable. Chemotherapy was selected as palliative treatment, also considering the patient's quality of life. Despite chemotherapy with cyclophosphamide 3, 400mg and radiotherapy with 60Co 30 Gy, the tumor grew rapidly in 4 months, and 120mg of adriamycin and 750mg of carboplatin were additionally administered. It was impossible to control tumor progression and the patient died of lung metastases in July 1991.
The patient was regarded to have suffered a radiation-induced malignant tumor judging from the criteria outlined by Cahan et al., Sato et al. and Sakai et al.
