Effect of Recombinant Human Insulin-Like Growth Factor-I on Expression of Glucose Transporters, GLUT 2 and GLUT 4, in Streptozotocin-Diabetic Rat

Takashi Asada; Toshikazu Ogawa; Michio Iwai; Masakazu Kobayashi

doi:10.1254/jjp.78.63

Short Communications

Effect of Recombinant Human Insulin-Like Growth Factor-I on Expression of Glucose Transporters, GLUT 2 and GLUT 4, in Streptozotocin-Diabetic Rat

Takashi Asada, Toshikazu Ogawa, Michio Iwai, Masakazu Kobayashi

著者情報

キーワード: Glucose transporter, Reverse transcription-polymerase chain reaction (RT-PCR), Immunohistochemistry

ジャーナルフリー

1998 年 78 巻 1 号 p. 63-67

DOI https://doi.org/10.1254/jjp.78.63

詳細

抄録

We investigated the effect of recombinant insulin-like growth factor-I (rhIGF-I) on the expression of glucose transporters, GLUT 2 in the liver and GLUT 4 in the heart, in streptozotocin (STZ)-diabetic rats by the reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. GLUT 2 and its mRNA in the liver was elevated, whereas GLUT 4 and its mRNA in the heart were decreased in STZ-diabetic rats. A two-week treatment with rhIGF-I mostly restored the expression of GLUT 2 and GLUT 4 to normal rat level. We demonstrated that the effect of IGF-I on the expressions of GLUTs was almost the same as that of insulin.

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