The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
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The Effect of Nipradilol on the Isoproterenol-Induced Depression of Contractions in the Cat Soleus Muscle
Toshihiko TanakaNozomu MurataYoichi Yamauchi
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1999 Volume 81 Issue 3 Pages 286-291


The effect of nipradilol on the isoproterelol-induced depression of contractions of the soleus muscle of the anesthetized cats was studied. Isoproterenol (0.3 μg/kg) injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anesthetized cats. The effect of isoproterenol was blocked by nipradilol (≥3 μg/kg), desnitro-nipradilol (≥10 μg/kg) and propranolol (≥10 μg/kg), but not by nitroglycerin (10 - 100 μg/kg). Nipradilol (30 μg/kg) and desnitro-nipradilol (300 μg/kg) almost completely antagonized the depressor effects of isoproterenol. These results coupled with evidence that nipradilol does not penetrate the blood-brain barrier indicate that nipradilol exerts an anti-tremor action by blocking peripheral β2-adrenoceptors.

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© The Japanese Pharmacological Society 1999
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