Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

Takao Shimazoe; Junichi Ishida; Miyuki Maetani; Tomohiro Yakabe; Masatoshi Yamaguchi; Kyoko Miyasaka; Akira Kono; Shigenori Watanabe; Akihiro Funakoshi

doi:10.1254/jjp.83.355

Short Communications

Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

Takao Shimazoe, Junichi Ishida, Miyuki Maetani, Tomohiro Yakabe, Masatoshi Yamaguchi, Kyoko Miyasaka, Akira Kono, Shigenori Watanabe, Akihiro Funakoshi

著者情報

キーワード: Streptozotocin, Suprachiasmatic nucleus, Entrainment

ジャーナルフリー

2000 年 83 巻 4 号 p. 355-358

DOI https://doi.org/10.1254/jjp.83.355

詳細

抄録

The term for re−entrainment to a new light−dark cycle in streptozotocin(STZ)−induced diabetic rats was significantly longer than that in control rats.In STZ−induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application.Therefore, 5−HT function in the hypothalamus is thought to be decreased in STZ−induced diabetic rats.These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ−induced diabetic rats.Therefore, 5−HT mechanisms may play an important role in the maintenance of this function.

責任著者(Corresponding author)

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