Expression of Cyclooxygenase mRNA in the Livers of Mice With Interferon-γ Chronic Hepatitis

Abstract

Interferon−γ(IFN−γ)transgenic mice expressed the IFN−γ gene in the liver and developed chronic hepatitis.The expression of cyclooxygenase(Cox)−1 and −2 mRNA were studied in the livers of these mice.A faint band of Cox−1 mRNA was observed in the livers of both normal and transgenic mice.Slight expression of Cox−2 mRNA was observed in the normal mouse liver, and this mRNA expression was induced in the transgenic mouse liver.The present results showed the induction of Cox−2 mRNA expression in the livers of transgenic mice with chronic hepatitis.