Induction of Apoptosis in a Human Breast Cancer Cell Overexpressing ErbB-2 Receptor by α-Tocopheryloxybutyric Acid

Akihiko Akazawa; Kazuhiro Nishikawa; Kazuyuki Suzuki; Ryuji Asano; Itsumaru Kumadaki; Haruna Satoh; Kiyokazu Hagiwara; Sung Jae Shin; Tomohiro Yano

doi:10.1254/jjp.89.417

Short Communications

Induction of Apoptosis in a Human Breast Cancer Cell Overexpressing ErbB-2 Receptor by α-Tocopheryloxybutyric Acid

Akihiko Akazawa, Kazuhiro Nishikawa, Kazuyuki Suzuki, Ryuji Asano, Itsumaru Kumadaki, Haruna Satoh, Kiyokazu Hagiwara, Sung Jae Shin, Tomohiro Yano

著者情報

キーワード: α-Tocopheryloxybutyric acid, Apoptosis, Breast cancer cell

ジャーナルフリー

2002 年 89 巻 4 号 p. 417-421

DOI https://doi.org/10.1254/jjp.89.417

詳細

抄録

The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of α-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death.

責任著者(Corresponding author)

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