Abstract
Our longitudinal exome-wide association studies previously detected a total of 210 genetic determinants of
nine complex disorders examined, using single nucleotide polymorphisms (SNPs) and longitudinal medical examination
data from 6022 Japanese individuals who have undergone annual health checkups for several years. According
to information on 1000 Genomes Project database, allele frequencies of seven disease-associated SNPs appear to
have largely changed since the divergence of East Asian and other ethnic groups. Of the seven SNPs, one might be a
Japanese-specific SNP associated with dyslipidemia. In this review, I summarize the East Asian- or Japanese-specific
genetic variants identified by our longitudinal exome-wide association studies in Japanese population.
