Abstract
Modern human (homo sapience) have spread out over the world during the ice age, this means they needed to
adapt to cold environments. Recent studies suggest that the importance of non-shivering thermogenesis (NST) generating
from brown adipose tissue (BAT), and the uncoupling protein 1 (UCP1) gene plays an important role in BAT
activity. Thus, this manuscript summarizes the relationship between human cold adaptation and the importance of
UCP1 genotype to individual and populational differences of NST.
