Abstract
A 31-day-old Japanese female was admitted to our hospital because of fever and leukocytosis. The peripheral white blood cell count was 63, 400/μl and a bone marrow examination showed 91.2% lymphoblasts of FAB L1 and karyotype of 46, XX, t (4 ; 11) (q21 ; q23). The immunophenotypes of the leukemic cells were HLA-DR (+), CD10 (-), CD19 (+) and CD20 (-). Early pre-B cell congenital acute lymphoblastic leukemia with CNS infiltration was diagnosed. Remission induction therapy for ALL protocol, CNS leukemia therapy with irradiation and reinforcement therapy for ANLL protocol were performed. Complete continuous remission was maintained for three years and she was removed from therapy. Today, the girl, who is now nine years and one month old, shows no psychomotor complications and seems to be enjoying life fully. Among the 22 reported cases of congenital ALL with t (4 ; 11), our patient is the longest surviving case.
