Juvenile Chronic Myelogenous Leukemia in Japan

A Report from Childhood Chronic Myelogenous Leukemia Study Group

Abstract

We retrospectively surveyed for juvenile chronic myelogenous leukemia in Japan. Fifty patients diagnosed from 1986 to 1995 were registered from 47 institutions. The median age of diagnosis was 2 yr 1 mo and the range was from 2 mo to 5 yr 6 mo. The male female ratio was 2 : 1. The overall survival of the evaluable 49 patients was 23.3%. The survival of 14 patients with allogeneic stem cell transplantation (SCT) and 35 patients without it was 49.0% and 13.7%, respectively. Total body irradiation was performed as the condition-ing regimen before SCT in 13 of 14 patients. Poor prognostic factors of the patients who did not receive allogeneic SCT were high age at diagnosis (≥ 2 yr), low platelet count (< 33, 000/μl), and mild splenomegaly (< 5 cm). Four of five patients who survived in good condition without intensive chemotherapy had been diagnosed before one year of age.