Sibling Cases of Childhood Leukemia -Elder Brother Developed Infantile Leukemia Twelve Years Prior to the Onset of His Younger Brother's Acute Myelogenous Leukemia-

Abstract

An 11-month-old male infant developed anemia and hepatomegaly. His illness was diagnosed as acute lymphoblastic leukemia. He was treated with conventional chemotherapy (CCLSG infant ALL874) and achieved a complete remission. Twelve years after occurrence of his leukemia, his younger brother presented pancytopenia at the age of 12 years. He was diagnosed to have acute myelogenous leukemia. He was also treated with conventional chemotherapy (CCLSG AML9805) and achieved a complete remission. We examined p53 mutation by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) in the brothers and no abnormality of p53 was noted. Because of the long interval between their onsets of leukemia and different types of leukemias, there would be different causes on the onsets of their leukemias. They are in continuous complete remission.