Abstract
We report a two-year-old girl with acute lymphoblastic leukemia (ALL) complicated with lung abscess under induction chemotherapy. Her leukemic cells showed L 1 morphology in a FAB-classification, CD10 and CD19 positive in surface markers, and 47, XX, + X, t (2; 11) (q11; q23) with MLL-LAF4 fusion protein. Under induction chemotherapy using the TCCSG L99-15 standard risk protocol, the patient showed persistent fever with an elevated level of CRP and infiltration in the right-middle lobe at a chest X-ray film. We failed to obtain the origin in several bacterial examinations. Anti-bacterial and anti-fungal agents did not induce the complete improvement of infiltration. Four months after diagnosis of lung abscess, the right-middle lobe was surgically resected and unrelated bone marrow stem cell transplantation was successfully performed. She is now well, in complete remission without any pulmonary complications.
