Current Status and Future Perspectives of Allogeneic Peripheral Blood Stem Cell Transplantation (PBSCT) in Children

Abstract

The number of patients undergoing allogeneic PBSCT in children is not increasing compared with that in adults, probably because donor safety of the procedure including administration of G-CSF has not been confirmed. The controversy about donor safety among physicians is always focused on the comparison of safety between bone marrow transplantation and PBSCT. However, both have similar potential problems for the donor, and offer tremendous benefits to the recipients in comparison with unrelated donors. One cannot draw a conclusion easily. In the present state, both alternatives should be explained in detail to the potential donors and their family.