Abstract
Multicenter studies show that intensive immunosuppression with antithymocyte globulin and cyclosporine restore the hematopoiesis in 60 to 70% of children with acquired aplastic anemia. The remaining 30 to 40% of children do not respond to the current drug regimens. Unresponsive children might suffer from a nonimmunologic disease. It is quite useful to develop a method which will predict responsiveness to immunosuppressive therapy.
