Successful Treatment of 3 Cases of Severe Aplastic Anemia by Plural Courses of Bolus Methylprednisolone Therapy

Abstract

Three children with severe aplastic anemia (SAA), essentially refractory to conventional therapy with oral steroids, were successfully treated by plural courses of bolus methylprednisolone (M-PSL) therapy. Two patients achieved hematological remission after two courses of therapy and one obtained partial improvement after four courses of therapy. All three became independent of transfusion; therefore, the therapeutic benefit of plural and bolus M-PSL therapy in the treatment of advanced-stage SAA, even in Fanconi's anemia, was confirmed.