Abstract
Severe acute respiratory syndrome (SARS) corona virus 2 (SARS-CoV-2) is a novel coronavirus that infects humans and causes respiratory symptoms, resulting in a global pandemic since its appearance in 2019. Neutralizing antibody production is an important immune response following SARS-CoV-2 infection, and a great deal of research has been performed regarding the immune response against SARS-CoV-2 infection. However, SARS-CoV-2 is constantly changing and multiple amino acid reconstitutions accumulated in the spike protein enabled viruses to escape from immune responses, especially from neutralizing antibodies. In this review, the antibody responses to SARS-CoV-2 and the emergence of escape variants, and the development of broadly neutralizing antibodies will be introduced.
