Abstract
To evaluate the efficacy of prophylactic systemic antibiotics with fosfomycin for prevention of post-transplant infections, 45 pediatric patients treated by bone marrow transplantation were allocated to prophylactic systemic antibiotics (PSA) group (22 patients) or control group (23 patients). The incidence of febrile episodes was lower in the PSA group (54.5%) than in the control group (78.3%), but it was not statistical significant. The afebrile period from the beginning of granulocytopenia (<500/μl) was significantly longer in the PSA group (11.4 ± 8.6 days) than in the control group (7.6±5.4 days). The febrile period during granulocytopenia was shorter in the PSA group (3.1 ±3.5 days) than in the control group (6.0 ±5.7 days). In bacterial examinations from throat swab, stool and urine cultures, the incidence of gram-negative bacteria isolation decreased but the incidence of fungus isolation increased in PSA group. Although prophylactic systemic antibiotics for prevention of bacterial infections in bone marrow transplantation is not common today, this result suggests its effectiveness and further study is needed.
