Abstract
We studied the different hematopoietic recovery after allogeneic and autologous bone marrow transplantation. Marrow recovery of myeloid (CFU-C) and erythroid (BFU-E) progenitor cells showed different repopulation kinetics between allogeneic (allo-BMT) and autologous (auto-BMT) bone marrow transplantation. Following allo-BMT almost normal numbers of CFU-C and BFU-E were detected at 2 weeks and 4 weeks, respectively.On the contrary, in auto-BMT, numbers of CFUC and BFU-E increased slowly and still reduced at 2-3 months after transplantation. Statistically, numbers of CFU-C at 2 weeks and BFU-E at 4 weeks were different significantly between the two groups. We suppose that the delayed recovery of hematopoiesis is due to suboptimal cryopreservation technique or hematopoietic impairment as a result of the chemotherapy or purging treatment, since transfused numbers of CFU-C and BFU-E were not different between allo-BMT and auto-BMT.
