1991 Volume 5 Issue 2 Pages 172-175
We reported a case of tuberous sclerosis with acute lymphocytic leukemia. A 9-year-old girl with tuberous sclerosis consulted her local pediatrician because of fever and general fatigue. The results of the examination of peripheral blood and bone marrow led to the diagnosis of acute lymphocytic leukemia, and she was admitted to our hospital. The blasts were positive for PAS stain, and negative for peroxidase stain. Surface marker analysis revealed that the blasts were positive for CD9, CD 10, CD 19, CD 20 and HLA-DR. She was treated with chemotherapy, and bone marrow remission was attained. Several cases of neurofibromatosis with leukemia are reported, but it is uncommon that tuberous sclerosis is complicated with leukemia.
