Abstract
We report here a case of juvenile chronic myelogenous leukemia preceded by idiopathic thrombocytopenic purpura (ITP) -like thrombocytopenia. The patient was a one-year-old boy with thrombocytopenia, increased megakaryocyte in bone marrow and no other hematological abnormalities. Prednisolone was effective in this thrombocytopenia. About 7 months later, severe thrombocytopenia, monocytosis and leukoerythroblastosis in peripheral blood appeared without increased blast cells in bone marrow. After 5 months, juvenile chronic myelogenous leukemia was diagnosed by hepatosplenomegaly and hematological findings such as remarkable leukocytosis, especially monocytosis, and increased hemoglobin F of fetal type. ITP-like symptoms at clinical onset might be considered the preleukemic stage of juvenile chronic myelogenous leukemia.
