1991 Volume 5 Issue 2 Pages 216-220
It is known that acute leukemia with 11q23 chromosome abnormality has unique characteristics. In this paper we reported an infant acute leukemia with t (6; 11) (p21; q23). A 5-month-old boy presented in October 1989 with complaints of fever and vomiting. On clinical examination he was found to have hepatosplenomegaly. His WBC was 83, 600/μl with 58% blast calls. Based on cell morphology and cytochemical examinations, he was diagnosed as having acute myelomonocytic leukemia (AMMoL; FAB M4). Cytogenetic analysis showed 73% (11 of 15) cells with t (6; 11) (p21; q23). He was treated with adriamycin, cytosine arabinoside, 6-mercaptopurine and prednisolone and attained complete remission. However, CNS relapse occurred after 6 months. He was treated with another ANLL protocol and obtained second complete remission. While the translocation involving band 11q23 such as t (4; 11), t (9; 11) and t (11 ; 19) has been reported in the literature, t (6; 11) (q27; q23) has been reported in only three cases and this abnormality, t (6; 11) (p21 ; q23), is the first case.
