Neutrophil ; Its Functions and Disorders

Abstract

Neutrophil is a white blood cell which plays an important role in microbial infection and inflammation. CD 11/CD18 on neutrophil membrane is an adhesive molecule binding bacteria opsonized with complement or endothelial cells. Chemotaxis, phagocytosis, or phagolysosome formation are regulated by GTP-induced polymerization of actin-filament. NADPH oxidase is activated with assambly of α- and β-subunit of cytochrome b558 on membrane and at least three kinds of cytosol factors. Congenital neutrophil dysfunctions are reported including leukocyte adhesion deficiency, Chediak-Higashi disease, and chronic granulomatous disease. Their etiology, clinical futures, and treatment were described.