Autologous Bone Marrow Transplantation in Children with Leukemia Lymphoma Syndrome

Abstract

Five children with leukemia lymphoma syndrome (LLS) in complete remission (CR) were received high-dose chemotherapy and/or total body irradiation followed by autologous bone marrow transplantation (ABMT). Autologous bone marrow was harvested at 1st CR in all patients and purged with 4-hydroperoxycyclophosphamide (4HC). Although one patient autografted in 2nd CR died of relapse, the other three patients in 1st CR are alive without relapse at +22m, +20m, + 11m. Especially, the treatment in two of them was finished within nine months from their diagnosis. Adverse effects of ABMT were a few and tolerable by the supportive cares. ABMT purged with 4HC would be effective and useful treatment in children with LLS.