Abstract
We report two cases of Ki-1 lymphoma in children. In case 1, enlargement of cervical lymph-nodes was the first clinical symptom. The COMP therapy achieved and sustained remission. A relapse in the primary site of lesion was noted after the therapy-off. However, we have succeeded in inducing the second remission. The first symptoms observed in case 2 were cervical adenopathy, fever, skin erythema, pleural effusion and ascites. Therapy under modified LSA2L2 protocol achieved remission which is still sustaining. Though immunologically and histologically, Ki-1 lymphoma is considered as an independent syndrome, clinically it shows diverse symptoms similar to so-called malignant lymphoma, and currently we are not yet able to find characteristic clinical features of this disease. There seems to be no need to clinically discriminate Ki-1 lymphoma from other malignant lymphoma, and the therapeutic method should be selected according to cell origin and disease stage.
