Abstract
We herein describe a case of a 16-year-old boy with chronic, presumably perinatally acquired, hepatitis B virus (HBV) infection, diagnosed with chronic active hepatitis on liver biopsy. Subsequently, this child developed pancytopenia, gammopathy, and positive autoimmune markers. No serologic evidence of other viral infection, in particular Epstein-Barr virus or cytomegalovirus, was found. Bone marrow biopsy revealed hemophagocytosis. This child's hematologic abnormality partially responded to steroid therapy. To the long list of protean disease manifestations associated with HBV infection, we have added infection-associated hemophagocytosis.
