がん化学療法ワークシートの開発と評価に関する研究

抄録

Cancer chemotherapy may cause a number of potentially serious adverse drug reactions (ADRs) that contribute significantly to morbidity and mortality. Because of this, pharmacists have to be responsible for verifying chemotherapy prescription orders, ADR monitoring and patient education. However, this is often complicated by the variety of cancer chemotherapy regimens that are used. Also, the shortage of hospital pharmacists and their lack of experience in pharmaceutical care during cancer chemotherapy make things even more difficult and leads to inefficiency. Thus, pharmacists need innovative tools to assist them in providing pharmaceutical care to these patients.
With this in mind, we have recently developed work sheets for the verification of prescription orders for chemotherapy agents, monitoring for potential ADRs, patient education, and providing information on ADRs and countermeasures to medical staff. Using the ADR monitoring sheet, we monitored a total of 671 ADRs, comprising 311 of grade 1 toxicity, 236 of grade 2, 98 of grade 3 and 26 of grade 4 according to the National Cancer Institute-Common Toxicity Criteria (version 2.0), in the oncology wards of our hospital. Of these ADRs, 538 cases (80.2%) were anticipated and occurred during the expected period, and most unanticipated events were either grade 1 or 2 toxicity. We concluded that our work sheets are potentially useful in the provision of efficient pharmaceutical care to patients undergoing cancer chemotherapy.