抄録
In Chu-no Kosei hospital, the setting of the initial dosage of vancomycin (VCM) by pharmacists to optimize trough and peak VCM concentrations against methicillin-resistant Staphylococcus aureus (MRSA) significantly reduced the mean duration of VCM therapy, prevented renal dysfunction, and achieved high clinical efficacy and economy in treatment.
In view of this, we developed a system for setting initial dosages called “TDM system for the setting of initial anti-MRSA drug dosages by pharmacists”. We also informed doctors and nurses about the basics of the system and TDM and created a TDM manual. As a result, in Chu-no Kosei hospital, the rates for attaining target VCM concentrations, and setting of initial VCM dosage by pharmacists rose significantly. In addition renal dysfunction could be prevented and high clinical efficacy achieved. Our system also enabled TDM to be conducted for all anti-MRSA drugs at Nishimino Kosei hospital, where TDM had previously not been practiced, and it produced the same clinical and economic benefits as at Chu-no Kosei Hospital. Our experience of introducing the system showed that it was very necessary to actively inform doctors and nurses concerning its use and TDM.
