アレルギー性薬疹における掻痒感の検討

抄録

We examined the occurrence of itching in 310 patients in whom allergic drug eruption was suspected and studied various aspects of itching for 221 leukocyte migration test (LMT)-positive patients.
The incidence of itching was 75.1% in the LMT-positives and 64.0% in LMT-negatives,a significant difference (p<0.05,χ²-test).In the former,there was a negative correlation between the incidence of itching and aging (correlation coefficient ; r=-0.78,p<0.01).As regards latent period,the incidence of itching was 65.0% in less than 3 days and 83.0% in more than 4 days,and this difference was also significant (p<0.05,χ²-test).Regarding leucocyte migration factors (LMFs),there was a signifant difference between the incidence of itching for the leukocyte migration activating factor (LMAF) which was was 82.2% and that for the leukocyte migration inhibitory factor (LMIF) which was 69.2% (p<0.05,χ²-test).In terms of causative drugs,the incidence of itching was 80.2% for antibacterial drugs and 62.5% for non-steroidal antiinflammatory drugs (NSAIDs),the difference again being significant (p<0.02,χ²-test).The detection rate of LMAF was significantly higher than that of LMIF for the antibacterial drugs (p<0.05,χ²-test),but in the case of NSAIDS,the LMIF detection rate was significantly higher than that for LMAF (p<0.00001,χ²-test).
Our findings indicate that the itching may arise as an allergic reaction in drug eruption and is present in 3/4 of allergic drug eruption cases.It also seems to be decreased by aging and to be influenced by the latent period,causative drug and LMFs.