2007 年 33 巻 7 号 p. 645-648
Doxorubicin and vincristine were added to various infusion solutions used for vincristine,doxorubicin and dexamethazone (VAD) chemotherapy.The infusion solutions were kept at room temperature,and stability was evaluated after 3,16,24,40,48,64,72,88 and 96 hours using high performance liquid chromatography.Doxorubicin and vincristine were stable in all infusion solutions up to 24 hours as residual contents were still over 90% at this time.Afterwards,a drop in vincristine content was observed for the infusion solution of physiological saline and this was considered to be due to adsorption of vincristine onto ethylene vinyl acetate copolymer,the material from which the infusion solution container was made.
