抄録
Many antibacterial agents are very bitter,which is sometimes a cause of non-compliance,especially in children.In the present study,using a taste sensor,we examined the bitterness of antibacterial agents and its suppression,and report the results together with those of related research conducted by another research group.This paper is divided into three main parts.The first is on the quantitative prediction of bitterness for several antibiotic solutions using a taste sensor,the second is on the application of the taste sensor to the prediction of bitterness of a clarithromycin dry syrup by itself and when taken together with various beverages or jellies,and the third is on the enhancement of bitterness due to dividing or crushing tablets containing antibacterial agents.Using the sensor,we could obtain a lot of quantitative information on the palatability of antibacterial agents,and we successfully demonstrated its usefulness.
