抄録
The purpose of this study was to investigate the relationship between blood concentrations of tacrolimus and liver biochemical profiles in living-donor liver transplantation recipients.The results indicated that the tacrolimus blood concentration/dose ratio (C/D ratio) decreased following living-donor liver transplantation.Furthermore,the variation in the C/D ratio and tacrolimus blood concentration was greater at 1 week after surgery than at 2-4 weeks afterwards.We also noted that when the C/D ratio was high total bilirubin was also high,suggesting that a low dosage of tacrolimus is necessary for hightotal bilirubin patients.However,there was no definite correlation between AST or ALT and the C/D ratio.It is therefore necessary to control tacrolimus blood concentrations in adult living-donor liver transplantation recipients.
