抄録
In order to contribute to antimicrobial stewardship, it is extremely important for pharmacists to apply PK / PD theory (combination of pharamacokinetics (PK) and pharmacodynamics (PD)) as well as the montecarlo simulation. However, very little useful PK / PD simulation software incorporating the montecarlo simulation is available for the clinical setting. We therefore developed easy-to-use software for this purpose based on Microsoft® Office Excel.
With it, drug clearance, volume of distribution, and PK / PD parameters are easily calculated using correlation equations derived from patient parameters, such as serum creatinine level and body weight, based on population pharmacokinetic parameters reported by various researchers. The montecarlo simulation is performed by generating pseudorandom numbers based on antibiograms, or interindividual coefficients of variation for each population pharmacokinetic parameter. We found that population pharmacokinetic parameters reported as following a 2-compartment model could be used as a 1-compartment model in the montecarlo simulation and report for the first time that the RN method (consisting of the RAND function and NORMSINV function in Microsoft® Office Excel) can be utilized as a pseudorandom number generator in the same manner as the MB method (consisting of Mersenne-Twister method and Box-Muller method).
Adoption of this software in the clinical setting will enable us to evaluate individual patient PK / PD parameter values and contribute to providing useful evidence for PK / PD theory.
