抄録
The purpose of this study was to identify the characteristics and risk factors of adverse drug reactions(ADRs) in the elderly. In a search of the case reports of adverse drug reactions and poisoning information system(CARPIS) database, which contains over 53,000 case reports of ADRs and poisoning, we obtained 949 cases in elderly patients and 824 cases in young patients. A comparison of ADR characteristics between the two groups using logistic regression analysis revealed that pharmacological ADRs, such as hypoglycemia and syndrome of inappropriate ant-diuretic hormone secretion(SIADH), tended to be more common in the elderly, while allergic ADRs, such as anaphylaxis and hepatic damage, were less common. ADRs in the elderly are more strongly associated with poor prognosis. Renal damage, comorbidities and polypharmacy were risk factors for ADR in the elderly, and the risk of ADRs in the elderly was significantly higher with leuprorelin, valacyclovir and cibenzoline. Renally excreted drugs also had a higher risk of ADRs in the elderly, and dosages were not adjusted in most ADR cases with renally excreted drugs. This information should be helpful in detecting and preventing ADRs in elderly patients.
