医薬品適正使用を目指した薬物相互作用・副作用症例の解析研究

抄録

It is important for proper use of prescription drugs to investigate adverse effects and drug-drug interactions in a case series of patients whom pharmacists encounter in clinical practice. If several risk factors for adverse effects and drug-drug interactions are identified by such investigations, they could be applied to predicting and preventing drug-induced adverse events. This paper describes an investigation of a case series to determine the risk factors in four examples, drug-drug interaction of oxycodone – voriconazole, tacrolimus – lansoprazole, and tizanidine – CYP1A2 inhibitors and Shakuyaku-Kanzo-To induced pseudoaldosteronism. The impact of the research outcomes is also discussed for indications on how to take the medicine on the package-insert of each drug.