Tablet-splitting is an important practice for pharmacists in hospitals and pharmacies. We investigated the variation of line tablet containing splitting score using 4 splitting methods (scissors, automatically, knife and spoon). We evaluated variation using the coefficient of variation. As a result, scissors and automatically showed small variation, but knife showed big variation. Furthermore, as individual difference using a warfarin tablet was investigated, the scissors showed small variation compared with other methods. As the splitting methods and individual difference results, the tablet scissors method was the most useful division method. We investigated the variation of line tablet non-containing splitting score using scissors and crushing tablet on/off diluting agent. As a result, crushing tablet on a diluting agent showed small variation. Using a score line tablet divided by the tablet scissors method, the non-score line tablet divided by crushing tablet on the diluting agent was small variation.
