To compare the efficacy and safety of hydro- and lipophilic strong statins in patients with type II diabetes mellitus and hyperlipidemia, we conducted a meta-analysis. We investigated the literature published before April 2013 using MEDLINE, CENTRAL, and Ichushi-Web. We adopted a randomized controlled trial design involving the administration of hydro- and lipophilic strong statins to patients with type II diabetes mellitus and hyperlipidemia. As parameters of the efficacy, serum lipid levels were used. Concerning the safety, several parameters, including the hemoglobin A1c value, were used. Of 299 reports, 9 were adopted. In the hydrophilic strong statin group, there was a significant decrease in the low-density lipoprotein cholesterol level. In addition, there was a significant increase in the high-density lipoprotein cholesterol level. Concerning the safety, there was a significant increase in the aspartate aminotransferase level in the hydrophilic strong statin group. There were no significant differences in any other safety parameter between the hydrophilic and lipophilic strong statin groups. The results of this study may contribute to clinical evaluation for the comprehensive treatment of patients with type II diabetes mellitus and hyperlipidemia.
