病院レセプトデータを用いた降圧薬の処方動向に関する調査

抄録

Details regarding trends in the prescription rates of antihypertensive drugs after 2011 are unclear. Therefore, we compared the prescription rates of antihypertensive drugs in 2009 with those in 2014 using claim records. Data were extracted from claims data provided from April-July 2009 and from April-July 2014 in Tohoku University Hospital, Sendai, Japan. Prescription rates were presented as the percentage of patients who were prescribed each drug. We compared the prescription rates in 2009 (n = 3,954, mean age 63.8 years, men 53.4％) with those in 2014 (n = 5,196, mean age 63.3 years, men 52.9％). The two most prescribed classes of antihypertensive drugs were angiotensin II receptor blockers and calcium channel blockers in both years (≥ 60％). No significant changes in the prescription rates for these two classes were observed between 2009 and 2014. The prescription rate for aldosterone blockers and αβ-blockers increased from 12.6％ and 8.4％ in 2009 to 16.9％ and 13.5％ in 2014 (P < 0.0001), respectively. In contrast, the prescription rate for angiotensin converting enzyme inhibitors and α-blockers decreased from 23.5％ and 10.4％ in 2009 to 15.6％ and 7.7％ in 2014 (P < 0.0001), respectively. The prescription rates for thiazide diuretics, non-thiazide diuretics other than aldosterone blockers, β-blockers, and other classes of antihypertensive did not differ significantly between 2009 and 2014. The prescription rates of antihypertensive drugs have changed based on new evidence regarding the drugs' mechanisms of action on hypertension or their adverse effects.