経腸栄養剤に使用する食物繊維および半固形化材へのフェノバルビタールの吸着の影響

抄録

In many hospitals, semi-solid enteral nutrients are administered. Dietary fibers are used as the main component of semi-solid agents, but some studies have reported that dietary fibers influence the bioavailability of drugs. In this study, we examined the influence of the adsorption of phenobarbital (PB) to dietary fibers and semi-solid agents used for the manufacturing of enteral nutrients. Five types of dietary fiber or 3 semi-solid agents were dissolved in 0.01％ PB solution to prepare concentrations of 1.0, 0.5, and 0.1％, and the adsorption rate and viscosity were measured. In PB solution containing 1.0％ guar gum, which was prepared with purified water, the adsorption rate of PB was 33.7％. It reduced with a decrease in the concentration of guar gum. The adsorption rate of PB to xanthan gum was also similar, although it was slightly lower than that to guar gum. There was no adsorption of PB to dextrin hydrate or cellulose under any condition. The first and second solutions established by the Japanese Pharmacopoeia also showed similar results. The results of this study indicate that the adsorption rates of PB to guar gum and xanthan gum were high. When administering drugs to patients receiving semi-solid enteral nutrients, the timing of administration at which there is no influence of adsorption must be reviewed.