内服薬の多剤併用簡易懸濁法における経鼻栄養チューブ通過性と有効成分の安定性の検討

抄録

In case of difficulty in oral drug administration to patients with dysphagia, the simple suspension method is useful for administering a drug by a nasogastric tube, and is used in many medical institutions. However, information on the simultaneous application of multiple drugs by the simple suspension method is insufficient. In this study, we used aspirin, clopidogrel sulfate, lansoprazole, atorvastatin calcium, and amlodipine besylate, which are commonly used in patients with cerebrovascular disease, to evaluate the suspensibility, nasogastric tube passability, and stability of the active ingredient in the simultaneous multiple suspension method. Under the conditions of four agents (excluding amlodipine besylate) and five agents, the entire suspension can be passed through the nasogastric tube by changing the nasogastric tube diameter or changing the suspending procedure, with no decreases in recovery of the active ingredient after passing through the nasogastric tube.

However, under the conditions for a combination of aspirin and clopidogrel, and for aspirin alone, the recovery rate of aspirin after passing through the nasogastric tube was low, suggesting that the simple suspension method should be applied carefully under a particular set of conditions. In the combination tested in this study, changes in formulation resulted in no decreases in the content of drugs, and the recovery rate after passing through the nasogastric tube was increased with an increase in the number of combined preparations. This information obtained by the present study might be useful for applying multiple drugs by the simultaneous suspension method.