2021 年 47 巻 8 号 p. 397-404
A drug-drug interaction (DDI) caused by a drug combination may cause clinical problems. This study evaluated the frequency and details of potential DDI (pDDI) in the discharge prescription and the relationship between pDDI and number of drugs used. The study included patients who were discharged from the rehabilitation ward for a duration of two years between 2018 and 2019. Lexicomp Drug Interactions, a DDI screening program, was used to detect pDDI. Clinically important pDDI was detected in 22.8％ (59/259) of patients. The DDI mechanisms were based on pharmacodynamic interactions in 63.6％ of cases and on pharmacokinetic interactions in 29.9％. Central nervous system depressant related pDDI was the most frequent type of pDDI detected. Use of hypnotics, antidiabetic drugs, antidepressants and antipsychotics was significantly higher amongst patients with detected pDDI. The incidence and frequency of pDDI increased with the number of drugs used. It is necessary for pharmacists to correctly evaluate the pDDI detected by the DDI screening program and contribute to the optimization of prescriptions and patient treatment.
