MPCポリマーの併用は市販ジクアホソルナトリウムまたはヒアルロン酸ナトリウム点眼液のドライアイ治療効果を高める

抄録

In this study, we investigated whether a combination of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer with commercially available diquafosol sodium (DIQ eye-drops) or sodium hyaluronate eye drops (HYA eye-drops) enhances the therapeutic effect for dry eyes. An N-acetylcysteine-treated rabbit model was used to evaluate the therapeutic effect for dry eyes in this study. The instillation of eye-drops containing DIQ and HYA enhanced mucin levels, and promoted the improvement in the tear film breakup in the N-acetylcysteine-treated rabbit model. In addition, the combination of MPC polymer increased the dry eye therapy in DIQ eye-drops and HYA eye-drops. Although the mucin levels in the N-acetylcysteine-treated rabbit model were also enhanced by the combination of DIQ eye-drops and MPC polymer, the mucin levels were similar between HYA eye-drops co-instillated with or without MPC polymer. These results show that the combination of MPC polymer may enhance the therapeutic effect for dry eyes in commercially available eye-drops.