地域薬局による潜在的食後高血糖リスク者の把握

抄録

The early treatment of postprandial hyperglycemia (PPHG) is important for preventing arteriosclerosis. Therefore, community pharmacies are expected to play an active role in its management. In this study, we first developed a simple screening method for PPHG that can be implemented in community pharmacies and then evaluated its usefulness in local residents.

To develop the screening method, five healthy adults in their twenties ingested 10.8 g of glucose, and their blood glucose (BG) levels were measured over time. Based on the observation that BG levels peaked 30 minutes after ingestion, a BG level ≥ 140 mg/dL at 30 minutes (BG-post) was defined as PPHG, and participants were classified into a high BG-post (Hi-BG-post) group.

Using this screening method, data were subsequently collected from local residents at a community health support event. Forty-nine participants with no history of diabetes or hyperglycemia and who were not receiving any medication were selected for the analysis.

The prevalence of Hi-BG-post was 49％. BG-post levels were significantly correlated with levels of low-density lipoprotein cholesterol (LDL-C), but not with pre-treatment BG levels (BG-pre) or HbA1c. Among individuals with Hi-BG-post, those with LDL-C ≥ 120 mg/dL had significantly higher blood pressure than those with lower LDL-C levels. The cut-off value of BG leading to this correlation was determined to be 44 mg/dL through multiple regression analysis.

These findings suggest that this simple screening method is a useful tool for identifying PPHG and indicate the possibility of early management by community pharmacies for local residents at risk of PPHG.