抄録
5% ethanolamine oleate (EO) as sclerosant in the treatment of esophageal varices was prepared under various conditions, and the stability of the solution at room temperature for 7 or 8 weeks was studied. Oleic acid in EO was meausred as an indicator for stability of the solution by means of gas chromatograph. It was found that dissolved oxygen-removed EO was more stable than untreated one. Neither treatment of N2 gas exchange in vial cavity nor autoclaving was essential to keep the content of oleic acid in EO for 8 weeks.
24 (88.9%) out of 27 patients with esophageal varices treated with endoscopic embolization using 5% EO made by our pharmacy were successfully treated. Frequency of complications and abnormal laboratory findings after treatment with the solution showed a rate which is roughly similar to the results reported by other researchers.
