Abstract
Compatibility of acetaminophen granules with 34 drugs was investigated by sensory test, while residual activity of acetaminophen in these admixtures was measured by absorptiometry to study the relation between the compatibility and residual activity (%). The data on change in compatibility with time were analyzed by scoring and were subject to a time series analysis (by 2 mean vector). A significant change in compatibility was observed in admixture with antipyrin, Neodrin S®, ephedrine hydrochloride, Hibon fine glanules®, and Narcotin® in the wetting, and with antipyrine and sulpyrine in the discoloration under the severe conditions (30°C, RH 92%). It was also observed in admixtures with antipyrine in the wetting and discoloration under the moderate conditions (20°C, RH 75%). Residual activity of acetaminophen with time was almost stable when tested alone and in mixtures.
No evident mutual relation was observed between compatibility and residual quantity.
