Abstract
Compatibility of riboflavin tetrabutyrate preparations (Modified syrup, Hibon syrup ®) with 45 medicines was investigated by sensory test, while residual potency of riboflavin tetrabutyrate was measured by absorptiometry. The data on change in compatibility with time were analyzed by time series analysis. A change of Modified syrup and Hibon syrup ® was showed in appearance, but wasn't observed in taste, odor, pH, residual potency and buffer capacity carve on every single syrup. In mixtures, a change was observed in appearance, taste, odor, but not in pH. Modified syrup, tested alone and in mixtures, was better than Hibon syrup in redispersion test. When we administer Hibon syrup ® mixture, we instruct patients to shake well before using.
