抄録
The comparative pharmaceutical quality evaluation of two commercial cimetidine tablets and fine subtilaes was made. The weight variation, content uniformity, hardness tests on tablets exhibited no significant difference between products, and both of which did not show pH dependency in disintegration and dissolution tests at pH 1.2, 4.0, and 6.8.
On the other hand, one of the fine subtilaes exhibited slightly lower dissolution rate at pH 1.2 and 6.8 because of its matrix formulation to suppress bitterness of cimetidine. The present study proved that all products have satisfactory quality, and complied with the requirements of the J. P. XI.
