割線入り錠剤の分割性に及ぼす圧縮圧の影響
1991 年 17 巻 1 号 p. 8-13
詳細
1991 年 17 巻 1 号 p. 8-13
The significance of compaction force on dividing properties of scored tablets was investigated in several tablets prepared from sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose (HPC) or potato starch as binder.
The influence of compaction force on dividing properties differed in incorporated binders and in particle sizes of tableting granules.The dividing strength of scored tablets increased with the increase of compaction force and, in some tablets, reached a plateau or decreased when compaction force exceeded a specific force. There existed a specific compaction force to minimize the weight variation of divided tablets, and effect of the particle size of tableting granules on uniform division became less when tablets were prepared at the specific compaction force.
