点眼剤の配合変化 防腐剤と配合変化の関係

山岡 桂子; 佐々木 真理子; 松井 正輝; 山本 裕子; 土屋 勝躬; 吉田 和夫; 米田 剛治; 竹谷 浩一; 船塚 政男; 植村 攻

doi:10.5649/jjphcs1975.17.149

Drug Interaction of Eyedrops

About the Relationship between Antiseptic and Drug Interaction

KEIKO YAMAOKA, MARIKO SASAKI, MASAKI MATSUI, YUKO YAMAMOTO, KATSUMI TSUTIYA, KAZUO YOSHIDA, TAKEHARU YONEDA, KOUICHI TAKETANI, MASAO FUNATSUKA, OSAMU UEMURA

Author information

Keywords: eyedrops, drug incompatibility, antiseptic, stability, ophthalmic drugs, additive, drug interaction

JOURNAL FREE ACCESS

1991 Volume 17 Issue 3 Pages 149-156

DOI https://doi.org/10.5649/jjphcs1975.17.149

Details

Abstract

We studied relationship between antiseptic and drug interaction in eyedrops used at Teikyo University Hospital.Two kinds of eyedrops were mixed and stored for 24 hours in a dark place at room temperature.Then the transparency was observed, and the content of main ingredient of each mixture of eyedrops was measured by HPLC.Combination of eyedrops containing benzalkonium chloride and containing ester of para-hydroxybenzoic acid often lead cloudiness. For some preparations, the decrease of drug contents was found without change of appearance.

Corresponding author

Register with J-STAGE for free!