Dividing property was investigated in scored tablets compressed by direct compression method. For the excipients, lactose (SL), corn starch (CS), synthetic aluminum silicate (SAS), hydroxy propyl starch (HPS), microcrystalline cellulose (MCC) and Perfiller® were used.Dividing strength of tablet was in the order MCC tablet>Perfiller® tablet>SAS tablet>SL, HPS and CS tablets.The dividing strength of SL-MCC and SL-Perfiller® mixture tablets increased with an increase of the mixing rate.But the dividing strength of SL-CS mixture tablet was unchanged.
Weight variation of tablet halves was affected by compaction profiles of excipients alone. MCC, SAS and Perfiller® showed straight compaction profiles, these tablets had little weight variation of tablet halves.But in the case of SL-CS, SL-MCC and SL-Perfiller® mixture, no difference of compaction profiles was shown and SL-MCC mixture tablet alone decreased the weight variation of tablet halves of SL tablet. Then a correlation between dividing strength of tablet and weight variation of tablet halves was found in SL-MCC and SL-Perfiller® mixture tablets.